High Field NMR Facility
The Center for Drug Discovery and Innovation offers state-of-the-art ultra-high field NMR instrumentation for the structural studies, especially in metabolomics, and biomacromolecular structural biology, etc. NMR core laboratory enables researchers to characterize protein structure at atomic resolution. The facility includes NMR spectrometers operating at 14 and 18 Tesla with associated HCN triple resonance cold probes that have carbon-enhanced and salt tolerant capabilities, which supply the highest possible 1H and 13C sensitivity for all applications. Technical support and training are available for all aspects of project development including feasibility studies as well as advanced protein-ligand interaction studies.
The resources of the NMR facility can be accessed either on a fee-for-service basis or on collaborative projects. The fee-based services include acquisition and analysis of the required spectra for structure elucidation of small molecules (e.g. synthetic molecules, natural products, and small peptides etc.). The collaborative projects include NMR solution structure determinations of biomacromolecules, protein dynamic studies, RDCs measurements, protein-protein (or with various ligands) interactions (Drug screening). Please contact us for more detailed information on NMR experiments conducting and collaborations.
CDDI core laboratories are equipped with the following instrumentation:
- Agilent VNMRS 600 and 800 MHz spectrometers with cold probes
Lab Location:
3720 Spectrum Blvd., Suite 105
IDR Building
Tampa, Florida 33612
Telephone:
(813) 974-5375
(813) 974-5391
Questions or Comments:
cddi@usf.edu
